TNF and rheumatoid arthritis: The recent development of biologics, such as tumor necrotic factor (TNF)-blocking agents, for the treatment of RA has improved the outcomes of the disease, and remission remains the ideal aim in patients with RA.1 Obtaining a prompt and accurate diagnosis and providing early aggressive treatment using biologics are keys to achieving effective management in cases of RA.2 As increased joint damage may cause functional impairments, it is important to inhibit radiographic progression and predict consequent joint destruction.