RDD was initially described by Destombes in 19653 and recognized as a distinct clinicopathological entity by Rosai and Dorfman in 1969.4 This disease is characterized histologically by an abnormal proliferation of histiocytes, typically with positive immunolabeling for S-100 protein and CD68, with engulfment of lymphocytes called emperipolesis. This evidence concerns the gene CD68 and sinus histiocytosis with massive lymphadenopathy.