IL10 and cancer: The genomic sequence of IL-10 gene is highly polymorphic and 3 promoter variants, viz -592C>A (rs1800872), -819C>T (rs1800871), and -1082A>G (rs1800896), in possible association with alterations of IL-10 function are well-defined from different populations with varying prevalence.4,5 It is reasonable to expect that if IL-10 is involved in the underlying pathological process of digestive cancers, the inherited genetic determinants that alter circulating IL-10 should affect cancer risk in the direction and magnitude predicted by its circulating level.