In univariate analysis, elevated IBS (P = 0.001) (Figure 1B), PI (P < 0.001), GPS (P < 0.001), mGPS (P < 0.001), raised AFP (P = 0.027), GGT (P < 0.001), lager tumor size (P < 0.001), multiple tumor number (P < 0.001), presence of microscopic vascular invasion (P < 0.001), poor cancer cell differentiation (P < 0.001), and advanced BCLC stage (P < 0.001) were identified as significant predictors of RFS. This evidence concerns the gene AFP and irritable bowel syndrome.