AFP and cancer: In univariate analysis, elevated IBS (P < 0.001) (Figure 1A), PLR (P = 0.001), PI (P < 0.001), GPS (P < 0.001), mGPS (P < 0.001), raised AFP (P < 0.001), GGT (P < 0.001), lager tumor size (P < 0.001), multiple tumor number (P = 0.001), presence of microscopic vascular invasion (P < 0.001), poor cancer cell differentiation (P < 0.001), and advanced BCLC stage (P < 0.001) were identified as significant predictors of OS.