Individuals with rs2839698 TT genotype had a significant increased risk of gastric cancer (OR = 1.64; 95% CI = 1.05–2.57) and carriers with rs2839698 T allele was significantly associated with higher H19 mRNA expression in cancer-free controls,22 suggesting a potential functional impact of H19 SNP on mRNA levels and the susceptibility to gastric cancer. The gene discussed is H19; the disease is gastric cancer.