And a borderline significantly decreased risk of bladder cancer was found for rs217727 T allele carriers compared with C allele carriers (OR = 0.74; 95% CI = 0.51–1.06).28 However, a previous study by Yang et al evaluated the effects of 4 independent SNPs (H19 rs217727, rs2839698, rs3741216, and rs3741219) on gastric cancer risk in the Chinese Han population and suggested that the T allele of rs217727 was associated with higher risk of gastric cancer in both codominant (OR = 1.34; 95% CI = 1.03–1.73) and recessive (OR = 1.48; 95% CI = 1.04–2.10) inheritance genetic models22. The gene discussed is H19; the disease is gastric cancer.