For example, HOTAIR has been widely identified to participate in tumor pathogenesis, acting as a promoter in colorectal cancer carcinogenesis.13 HOTAIR rs7958904 CC decreased the risk of colorectal cancer compared with GG genotype14 and HOTAIR rs920778 TT carriers had increased gastric cancer risk.15 Increased breast cancer risk was associated with the lincRNA-ENST00000515084 rs12325489 CC and CT genotype when compared with the rs12325489 TT genotype.16 rs11752942 AG+GG in the lincRNA-uc003opf.1 exon had a significantly reduced risk of esophageal squamous cell carcinoma.17 This evidence concerns the gene HOTAIR and esophageal squamous cell carcinoma.