LncRNA H19 is an imprinted gene, located on human chromosome 11p15.5, encodes a 2.3-kb long, capped, spliced, and polyadenylated noncoding RNA.18 H19 is abnormally expressed in several tumors, and it acts as either a tumor suppressor,19,20 or an oncogene.21 Increasing evidence suggests that H19 genetic variants play important roles in the development of cancers. This evidence concerns the gene H19 and cancer.