KLK3 and posterior cortical atrophy: In this scenario, an emerging entity is represented by the prostatic evasive anterior tumor syndrome (PEATS), a condition characterized by combination an aggressive and anterior PCa that manifests as rising PSA values in patients with previous negative TRUS-guided biopsy.28 These data highlight the importance of performing a PBx using a transperineal approach in high-risk patients with prior negative transrectal biopsy.