Many studies demonstrated that the risk of a large prostate volume to result in a reduced probability of sampling malignant tissue is low.24,25 Zackrisson et al found that, among 456 men with 1 set of benign PBx and who underwent 2 additional sets of 18-core PBx, in no cases of prostates with volume of <20 mL, either PCa or PSA normalization was found.24 Similarly, van Leeuwen et al found that, among 1305 men with an initial benign PBx, those with smaller prostates and high PSA values had, in the following 8 years, an increased risk of PCa detection and of a more aggressive tumors.25 Here, KLK3 is linked to posterior cortical atrophy.