A large multicenter screening study, whereby 264 of 6630 patients were diagnosed with PCa, revealed that the absence of urinary symptoms predicted PCa; however, no validated symptom score questionnaire was used.20 Another large screening study, whereby 2467 out of 65,871 men were diagnosed with PCa, showed that a history of LUTS improved the prediction of an individual's risk for PCa, but also that LUTS among men with a PSA level ≥3 ng/mL were negatively associated with PCa.21 Again, no validated symptom score questionnaire was used. This evidence concerns the gene KLK3 and posterior cortical atrophy.