As we had previously observed that lack of H-2Kb molecule resulted in a very drastic reduction of the Ad-YF NS3 induced protection in vivo (10% in H-2Kb KO mice vs. 100% in B6 mice), we wanted to confirm that NS3 vaccinated H-2Kb deficient mice would not be able to control YF-17D infection of the CNS following intracranial challenge. The gene discussed is KRAS; the disease is infection.