ITGAX and infection: The only other notable difference in the spleen between the two treatment groups was a significantly higher proportion of CD11c+MHCII+ DCs, CD11clowCD11bhighLy6C+CD64+ macrophages, and Ly6Chigh monocytes (which typically traffic to the sites of infection or inflammation and differentiate into classical macrophages that secrete pro-inflammatory cytokines) and a significantly lower proportion of Ly6Clow monocytes (secrete anti-inflammatory cytokines) in mice infected with parasites conditionally depleted of PTEX88 (S3C Fig).