CD8A and cerebral malaria: Although we did not observe a difference in the proportion of immune cells in the spleen in mice infected with wildtype or depleted levels of PTEX88, it would be worthwhile undertaking further studies to examine whether the differences in the pathology of the two groups of mice is the result of reduced infiltration of CD8+ T cell numbers in the brain, particularly as these cells are known to contribute to the induction of cerebral malaria in experimental murine models [46].