The discovery of the two main types of thyroid hormone receptors (TRs TRα and TRβ) [8] as well as the development of combinational chemistry to provide organ specificity has drastically improved the selectivity of thyroid hormone mimetics, and some have shown to significantly reduce atherosclerosis in apolipoprotein E (ApoE) knockout mice, an established pre-clinical model for atherosclerosis [9–11]. The gene discussed is APOE; the disease is atherosclerosis.