In oesophageal cancer, Hamano et al reported that overexpression of miR-200c was significantly correlated with poor response to cisplatin-based chemotherapy, potentially through up-regulation of the Akt-pathway (PPP2R1B) [10] and Tanaka et al showed that high pre-treatment expression levels of miR-200c in serum were significantly associated with impaired response to cisplatin-based chemotherapy [11]. This evidence concerns the gene PPP2R1B and carcinoma of esophagus.