To assess the role of the GSK-3-T-bet-PD-1 pathway in LCMV-Cl13 infection, mice were infected i.v. with the LCMV-Cl13 variant followed by an injection with SB415286 at day 25 when exhaustion had been established in the chronic phase of the infection (Figure S5C). The gene discussed is PDCD1; the disease is infection.