CD4 and neoplasm: On the other hand, according to Ramello et al, after co-incubation with CD4+ or CD8+ tumor-induced senescent T cells, monocytes produce more pro-inflammatory cytokines (TNF, IL-1β and IL-6) and angiogenic factors (MMP-9, VEGF-A and IL-8) than those co-cultured with controls [32].