However, the phosphorylated FAK, total paxillin and phosphorylated paxillin decreased dramatically in MCL cells treated with LDE225 compared with cells treated with DMSO (Figure 2A, Supplementary Figure S5), suggesting that inhibition of Hh signaling resulted in the disruption of the FAK signaling pathway in MCL cells. This evidence concerns the gene PXN and mantle cell lymphoma.