Eight keratoconic corneal buttons harvested from the 8 advanced keratoconus patients with superficial stromal scarring underwent immunohistochemistry staining, and the scar regions expressed high immunogenicity of fibroblast activation proteins (FAP), vimentin, and α-smooth muscle actin (α-SMA) (Figures 5 and 6). The gene discussed is ACTA1; the disease is keratoconus.