MACC1 and adenoma: It may also affect levels of MMP-2 and MMP-9 [89]. MACC1 promotes the carcinogenesis of CRC and is associated with the transition from adenoma to carcinoma and the invasive growth of early CRC [90]. MACC1, HGF, and MET are all located on chromosome 7 and amongst their neighbors are genes that are known to be involved in signal transduction and regulation of cell adhesion and motility.