SNPs SCN4A-rs2302237 and SCN10A-rs1263292 emerged as being significantly associated with an increased incidence of acute oxaliplatin-induced peripheral neuropathy. SCN4A-rs2302237 emerged also as being predictive of the clinical severity of acute oxaliplatin-induced peripheral neuropathy and the occurrence of cumulative/chronic oxaliplatin-induced peripheral neuropathy. This evidence concerns the gene SCN4A and peripheral neuropathy.