It may also affect levels of MMP-2 and MMP-9 [89]. MACC1 promotes the carcinogenesis of CRC and is associated with the transition from adenoma to carcinoma and the invasive growth of early CRC [90]. MACC1, HGF, and MET are all located on chromosome 7 and amongst their neighbors are genes that are known to be involved in signal transduction and regulation of cell adhesion and motility. This evidence concerns the gene MMP2 and colorectal carcinoma.