Cecchin et al. [64] conducted a study concerning MTHFR 1298A>C (rs1801131) polymorphism as a predictor of survival in two cohorts of stage II/III setting of CRC patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. MTHFR 1298CC genotype carriers had worse disease free survival and also worse overall survival in both cohorts. Here, MTHFR is linked to colorectal carcinoma.