However, we cannot firmly rule out this account since A549 (wild-type p53) and H1299 (p53-deficient) cells, representing two histopathological subtypes of lung cancer, also exhibited a distinct interaction pattern, and simultaneously it is possible that in the MCF-7 cells, the antagonistic interactions between FIS and PTX might be determined by other factors. Here, TP53 is linked to lung carcinoma.