In our study, we choose the mouse KP2 cell (Kras mutation and p53 deletion) and human H23 cell (Kras mutation and p53 mutation) with high expression level of HK2 as research models, we found 2-DG not only inhibits KP2 and H23 cell growth in vitro, but also decreases tumor proliferation in SCID mice bearing KP2 lung cancer cells. Here, TP53 is linked to neoplasm.