In line with this view, the overall aim of this study was to evaluate the mRNA-peripheral blood profile of two HER2− breast cancer subtypes, including hormone-dependent breast cancer (ER+PR+HER2−) and triple-negative breast cancer (TNBC/ER−PR−HER2−), known to have the best and the worst prognosis, respectively. This evidence concerns the gene ERBB2 and breast carcinoma.