The role of cytokines, such as TNF-α and IL-6, in the pathophysiology of acute pancreatitis has been studied extensively and they have been found to contribute to the activation of the systematic inflammatory response process and multiorgan failure, which is a hallmark of severe acute pancreatitis and is, ultimately, correlated with the observed high mortality rates [10, 11]. This evidence concerns the gene TNF and acute pancreatitis.