However, there are also some differences: rs6678914, LGR6 and rs865686, 9q31.2 are strongly associated with LCIS but there is little evidence of association with ER+ DCIS (P-HetDCIS/LCIS = 7.4 × 10-5 and 6.6 × 10-4, respectively). This evidence concerns the gene LGR6 and ductal breast carcinoma in situ.