A recent study investigating the association between 39 of the known breast cancer predisposition loci and breast cancer in situ (BCIS) suggested that rs1011970 (9p21.3, CDKN2BAS) had a stronger association with BCIS than invasive breast cancer (BC), P-HetBCIS/BC = 0.0065. This evidence concerns the gene CDKN2B-AS1 and invasive breast carcinoma.