There were also no significant differences in PD-L1 expression levels in TAM and tumour cells (CD45−EpCAM+) and levels of the cytokines IL-6 in bronchoalveolar lavage fluids (BALFs), that can promote tumour growth18, 19, between untreated (U) and PD-1 treatment-resistant mice (R) (Supplementary Fig. 1c,d) though the level of IL-6 in BALFs showed a clear reduction in PD-1 treatment-sensitive animals (S) as we previously demonstrated in a different EGFR mutated model17. Here, IL6 is linked to neoplasm.