Several differentially presented glycoproteins in HCC plasma that were previously reported as candidate cancer biomarkers exhibited the same tendency in our analysis: levels of α2-macroglobulin (A2M)31, 32, sex hormone–binding globulin (SHBG)31, 33, and complement component C734, 35 were elevated in HCC plasma, whereas levels of SERPINA535 and laminin (LAMC1)36, 37 were reduced. Here, SHBG is linked to cancer.