A2M and cancer: Several differentially presented glycoproteins in HCC plasma that were previously reported as candidate cancer biomarkers exhibited the same tendency in our analysis: levels of α2-macroglobulin (A2M)31, 32, sex hormone–binding globulin (SHBG)31, 33, and complement component C734, 35 were elevated in HCC plasma, whereas levels of SERPINA535 and laminin (LAMC1)36, 37 were reduced.