In the initial phases, infection with the AA43 and AA44 CF-adapted variants yielded lower recruitment of innate immune cells, including neutrophil and macrophage (Fig. 2A,B), and less MIP-2, KC, MIP-1α, IL-6, MCP-1 and TNF-α cytokines/chemokines production than AA2 (Fig. 3A–F). This evidence concerns the gene CALCA and infection.