Although mean ADC and FDG-PET/CT maximum SUV of HCC in patients on waiting list for LT are not correlated, both tumour size, poor differentiation and AFP levels correlate with SUVT/L, suggesting that FDG-PET/CT can predict tumour aggressiveness and should probably be integrated as a covariable in a predictive outcome model of patients with HCC candidate to LT, while MRI must be used for lesion detection and characterization. This evidence concerns the gene AFP and hepatocellular carcinoma.