Several studies have reported that pre-LT PET/CT with [18F] 2- deoxy-2-fluoro-D-glucose (FDG) may play a role in predicting tumour recurrence [10–15] in high-grade HCC tumours, which have a reduced glucose-6-phosphatase activity, resulting in progressive accumulation of the tracer within tumour cells as compared to adjacent liver. Here, G6PC1 is linked to hepatocellular carcinoma.