This region has not been previously described as a control region for RUNX1 but analysis revealed that areas within this region encompassing EBNA2 binding sites are classified as super-enhancers in specific cell backgrounds, including the Diffuse large B cell lymphoma cell-lines Toledo and HBL1, the Breast cancer line HCC1954, mammary epithelial cells and skeletal muscle (dbSUPER, http://bioinfo.au.tsinghua.edu.cn/dbsuper/ (48)). Here, RUNX1 is linked to breast carcinoma.