RUNX3 and Burkitt lymphoma: To elucidate the mechanism of EBNA2 activation of RUNX3 in EBV infected cells we examined EBNA2 binding data obtained by ChIP-sequencing from two EBV-infected cell lines, one a Burkitt's lymphoma cell line expressing the full panel of EBV latent genes (Mutu III (16)), and the other the Tier 1 ENCODE EBV-immortalized lymphoblastoid cell line GM12878.