CCND1 and cancer: Representative Cyclin D1 target genes were chromosome segregation factors such as AURKB and CENPM (Fig. 3D) that have previously been identified as targets of Cyclin D1 in mouse embryonic fibroblasts (Casimiro et al. 2012) and have been implicated in chromosome instability in cancers (Thompson et al. 2010; Casimiro and Pestell 2012; Pestell 2013).