ICAM1 and neoplasm: Polypeptides which showed potent binding affinity of tumor cells or tumor microenvironment, such as intercellular adhesion molecule-1 (ICAM-1), Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR), have already been used as carrier for drug delivery in cancer therapy due to their smaller molecular weight and lower undesirable immunogenicity than ADCs11, 12.