Considering the key role of SREBP-2 in regulating cholesterol metabolism, we determined the expression of its canonical targets, including 3-methyl-glutaryl-CoA synthase 1 (HMGCS1), 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), mevalonate kinase (MVK), mevalomate 5-pyrophosphate decarboxylase (MVD) and low-density lipoprotein receptor (LDLR) in PCa cells with genetically manipulated SREBP-2. This evidence concerns the gene HMGCR and posterior cortical atrophy.