This SREBP-2-induced phenotypic switch of PCa cells is accompanied by markedly increased expression of mesenchymal-associated markers or regulators, including N-cadherin, Vimentin, Snail2 and ZEB1, and decreased production of an epithelial-specific marker, E-cadherin (Supplementary Figures S10B and S10C). Here, CDH2 is linked to posterior cortical atrophy.