SREBF2 and neoplasm: In line with the observation that inhibition of CWR22Rv1 cell growth in vitro by silencing of SREBP-2 (Figure 2D, right panel), a significantly reduced tumor growth rate and smaller tumors were observed in SREBP-2 knockdown CWR22Rv1 tumor xenografts compared with control tumors (Figure 6A, 6B and Supplementary Figure S7B).