In order to prove that SREBP-2 induces stemness through c-Myc regulation, loss- and gain-of-function experiments were conducted in SREBP-2-manipulated PCa cells, which showed that RNAi-mediated c-Myc knockdown reverted stem cell-like properties induced by SREBP-2 and decreased expression of ALDH1A1 and CD44 in SREBP-2-overexpressing LNCaP cells. This evidence concerns the gene ALDH1A1 and posterior cortical atrophy.