To further investigate whether stem cell-like properties induced by SREBP-2 in PCa cells could be contributed by cholesterol metabolism, simvastatin, an inhibitor of HMGCR blocking a primary and rate-limiting step for cholesterol biosynthesis, and exogenous cholesterol were used to treat PCa cells with genetically manipulated SREBP-2. The gene discussed is HMGCR; the disease is posterior cortical atrophy.