Quantitative analysis revealed reduced expression of SREBP-2, c-Myc, ALDH1A1 and CD44 in both organs subjected to SREBP-2 silencing compared with control tumors (Supplementary Figure S8C), suggesting that the inhibition of metastasis by silencing SREBP-2 in PCa metastasis occurs through inhibiting c-Myc expression. Here, SREBF2 is linked to posterior cortical atrophy.