In animal studies, we demonstrated that SREBP-2-overexpressing LNCaP cells (only 2,000 cells) were able to develop subcutaneous xenograft tumors in mice while knockdown of SREBP-2 in CWR22Rv1 cells inhibited tumor growth and metastasis in the xenograft models along with decreased expression of stemness-related genes, including c-Myc, ALDH1A1 and CD44. This evidence concerns the gene SREBF2 and neoplasm.