CRIP2 and breast carcinoma: To further characterize the function of CRP2 in breast cancer cells, a series of in vitro functional assays were conducted with two MDA-MB-231-luc-derived cell lines expressing independent CRP2-targeting shRNAs (shCRP2a and shCRP2b), and one control cell line expressing a non-targeting control shRNA (sh-; Figure 4A).