For some cell lines, e.g. MCF7, with with amplification of the PPM1D chromosomal locus or some patient derived tumor cell explants with overexpressed Wip1, the uncontrolled cell cycling and extended resistance to apoptosis was supported by the fact of negative influence of elevated Wip1 levels on activity of p53 pathway [40]. The gene discussed is PPM1D; the disease is neoplasm.