TARDBP and neuroblastoma: Our studies also show that the TDP-43 D169G mutant could be cleaved more efficiently by caspase 3 to generate higher levels of TDP-35 in vitro, and the expression of the D169G TDP-43 mutant in mouse neuroblastoma cells consistently generated higher levels of TDP-35 than that of the wild-type TDP-43 (Figs 4 and 7).