Interestingly, early ALS disease onset has been correlated with the increased stability of TDP-43 from 12.6 hours for the wild-type to 15.9–50.6 hours for seven ALS-linked mutants, G298S, A315T, M337V, Q343R, G348C, N352S, A382T, suggesting that TDP-43 protein stability is directly associated with ALS pathogenic pathways47. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.