ALS-linked mutants have been suggested to be more prone to aggregation and more potent in inducing cell death than wild-type TDP-43: Compared to the latter, Q331K and M337V accelerate spontaneous TDP-43 aggregation39, A315T, G348C and A382T induce neuron cell death40, 41, and Q331K and M337V more strongly induce oxidative injury of motor-neuron like cells42. Here, TARDBP is linked to amyotrophic lateral sclerosis.