In contrast to the series of the investigation, Fu et al. reported the rise of PC/PE ratio and upregulation of Pemt in hepatic endoplasmic reticulum (ER) in obesity, which resulted in reduced calcium transport activity of sarco/endoplasmic reticulum calcium ATPase (SERCA) and enhanced ER stress35. The gene discussed is PEMT; the disease is obesity due to melanocortin 4 receptor deficiency.