In addition, because the frequency of mucinous histology was remarkably higher in MLH1-methylated CIMP-H CRC (73%; Table 1) than in MSI-H, CIMP-L/0 CRC (36%; Supplementary Table S3), there may be a synergistic impact of MSI-H and CIMP-H on mucinous differentiation in CRC. This evidence concerns the gene MLH1 and colorectal carcinoma.