In fact, KRAS-mutated TSA has been regarded as an aggressive serrated lesion that is significantly associated with high-grade dysplasia and intramucosal adenocarcinoma and is frequently found in combination with MGMT and CDKN2A methylation, TP53 mutations, and Wnt pathway activation, suggestive of the combined activity of the CIMP and CIN pathways [23, 26]. This evidence concerns the gene CDKN2A and cervical squamous intraepithelial neoplasia.