The MLH1-methylated tumors frequently exhibited abundant mucin pools, intense peritumoral lymphoid reactions, and active Crohn-like lymphoid reactions, whereas the MLH1-unmethylated tumors were associated with non-mucinous-type adenocarcinoma and the absence of peritumoral lymphoid reaction and Crohn-like lymphoid reaction (Figure 2). This evidence concerns the gene MUC5AC and adenocarcinoma.