MLH1 and colonic neoplasm: Of these, the MLH1-silenced tumors were significantly associated with female sex (79%; P = 0.003), proximal colonic tumor location (100%; P = 0.031), MSI-H status (96%; P < 0.001), an exome-wide hypermutated phenotype (95%; P < 0.001), wild-type KRAS (95%; P < 0.001), and mutated BRAF (75%; P < 0.001) (Table 3).