In fact, the significant overlap between MSI-H and CIMP-H in CRC is not surprising because nearly all sporadic MSI-H CRCs are molecularly based on the promoter CpG island hypermethylation-induced silencing of the MLH1 gene, which is also found in a considerable number of CIMP-H CRCs. The gene discussed is MLH1; the disease is colorectal carcinoma.