Although different serrated pathways to CRC remain to be further understood, our findings suggest that MLH1-methylated CIMP-H CRC may be derived typically from the SSA/P pathway but that MLH1-unmethylated CIMP-H CRC may develop mainly through the KRAS-mutated TSA pathway and also less commonly through the BRAF-mutated TSA pathway and/or the SSA/P pathway (Figure 4B). This evidence concerns the gene MLH1 and colorectal carcinoma.