Two of the MLH1-non-silenced tumors were distant metastatic tumors (17%; Table 3) and three were rectal tumors (25%; Table 3 and Figure 3B), whereas the MLH1-silenced tumors showed no distant metastasis or distal colorectal localization (Table 3 and Figure 3B). The gene discussed is MLH1; the disease is metastatic neoplasm.