CIMP-H CRC with MLH1 methylation (n = 33) was significantly associated with old age (66 years or older; P < 0.001), a proximal colonic tumor location (82%; P = 0.026), extracellular mucinous histology (73%; P < 0.001), high-density tumor-infiltrating lymphocytes (TILs) (58%; P < 0.001), moderate to marked peritumoral lymphoid reaction (53%; P = 0.002), and active (34%; P = 0.005) and high-density (69%; P = 0.024) Crohn-like lymphoid reaction (Table 1). Here, MLH1 is linked to neoplasm.