IGKV1D-22 and carcinoma: In carcinoma cells, calprotectin (S100A8/A9; MRP8/14), a heterodimeric complex of calcium-binding proteins, S100A8 and S100A9, appears to suppress cell cycle progression, growth, and migratory invasion by regulating cell differentiation and adhesion to extracellular matrix (ECM) [1-5].