To show whether reduction of S100A8 and/or S100A9 expression contributes to HNSCC tumorigenesis, we enumerated the number of HNSCC samples (TCGA data) in which S100A8, S100A9, or both were downregulated relative to the mean expression in normal adjacent samples (Figure S1A). This evidence concerns the gene S100A8 and head and neck squamous cell carcinoma.