The data from the current study demonstrated that PCV2 Cap activated PI3K/Akt, p38 MAPK, and ERK signaling pathways, but only PI3K/Akt signaling was involved IL-10 induction in the both early and late phase of PCV2 inoculation in macrophage, while PCV2 Cap protein binding with host gC1qR to induce IL-10 production at the both early and late phase of infection. The gene discussed is AKT1; the disease is infection.