Considerable evidence showed that chemokines and its receptors are closely related with some biological properties of cancer stem cells [23, 24], so our research team wondered whether the CXCL9 and CXCR3 receptors are able to affect the CD133+ liver cancer cells, and isolates CD133+ cells from Huh7, Hep-3B, and PLC/PRF/5 cell lines to start further research. This evidence concerns the gene PROM1 and liver cancer.