Table 1 shows the characteristics of the ACEI/ARB group (n = 52) and the non-ACEI/ARB group (n = 249). There were 112 patients who received sequential treatment with TKIs. The baseline characteristics were generally the same in the ACEI/ARB and non-ACEI/ARB groups. The characteristics of particular patient subgroups, including advanced NSCLC patients, patients who underwent surgery and EGFR-TKI-treated patients, are shown in supplementary Table 3. In total, 103 patients received medication for hypertension (Table 2). The gene discussed is EGFR; the disease is hypertensive disorder.