In pancreatic adenocarcinoma, C14orf166 is overexpressed in the serum of patients with pancreatic adenocarcinoma detected by surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF–MS), and is a potential biomarker for pancreatic adenocarcinoma [15]. This evidence concerns the gene RTRAF and pancreatic adenocarcinoma.