Considering the necessity of ubiquitination for the TAK1 autophosphorylation/activation and the K63-polyubiquitination catalysis ability of TRAF3 (refs 35, 36, 37), we examined whether an involvement of TAK1 ubiquitination exists in the TRAF3-regulated development of fatty acid metabolic disorder. The gene discussed is TRAF3; the disease is inherited fatty acid metabolism disorder.