IFNB1 and systemic lupus erythematosus: From the upper cluster, 5 out of 7 IRGs (GC-A) were significantly upregulated in SLE patients compared to MS-IFNβ, whereas 13 out of 16 genes (GC-B) from the lower cluster were significantly upregulated in the IFNβ-treated MS patients compared to SLE (Fig. 2a and Additional file 1: Table S2).