In addition, HNSCC also have multiple genomic alterations, such as PTEN mutations (2.8 %) and gene copy number loss (31.0 %) and activating mutations in RAS (5.9 %) and AKT (2.2 %) genes that result in PI3K/mTOR pathway activation. The gene discussed is MTOR; the disease is head and neck squamous cell carcinoma.