BSG and hepatocellular carcinoma: On the premise of almost equally CD147 expression (Supplementary Figure S1E and S1F), CD147wt rendered the cells highly sensitive to AC-73 whereas three cell lines expressing the single glutamate mutants or a double mutant (E64A and E73A) were less sensitive, suggesting that Glu64 and Glu73 of CD147 are indispensable for AC-73-dependent inhibition of CD147-mediated HCC invasion (Figure 7E and 7F).