Given that our previous findings about TAL1-transcriptionally regulated miRNA expression [27] did not recognize miR-101 as a possible transcriptional TAL1 target, the low expression of the miRNA found in primary T-ALL samples and cell lines foresees a tumor-suppressive role for miR-101 in T-cell transformation, which might be in part mediated through down-regulation of TAL1 rather than EZH2. The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.