The tumor suppressive function of miR-101 in inhibiting cell proliferation, migration, invasion and tumor growth, has been demonstrated in prostate [43], bladder [44], gastric [45, 48], and renal cell [49] carcinoma, pancreatic ductal adenocarcinoma [50] and melanoma [52], mainly due to targeting of the histone methyltransferase EZH2. This evidence concerns the gene EZH2 and melanoma.