Putative poly-adenylation sites are present in the 3427 nt-long TAL1 3′UTR: two close AAUAAA poly-adenylation sites at positions 3052 and 3413 and one alternative AAGAAA poly-adenylation site at 1300, raising the possibility that shorter transcripts could exist in T-ALL cells that would exclude the MRE of some of the targeting miRNAs, consequently rendering TAL1 more ‘resistant’ to miR-mediated downregulation and thereby promoting TAL1 overexpression. Here, TAL1 is linked to acute lymphoblastic leukemia.