TAL1 and acute lymphoblastic leukemia: Given the relatively mild effects of each miRNA on TAL1 protein expression, which are in accordance to what is described for microRNA post-transcriptional regulation [37, 38], we do not foresee that their deregulated expression can fully justify the high levels of TAL1 ectopic expression observed in T-ALL patients, unless it occurred in a coordinated fashion involving several TAL1-targeting miRNA genes as a consequence of a putative common upstream event.