Therefore, bioinformatics analysis was performed to predict the potential regulation interactions between miRNAs and CTNNA3. As predicted by miRanda [27] and TargetScan [28], 23 miRNAs have high complementarity to the 3′UTR of CTNNA3. Among them, only miR-425 was found to be up-regulated (P-value < 0.05 & LgFC > 0.5) in the 13 HCC samples. The gene discussed is CTNNA3; the disease is hepatocellular carcinoma.