Furthermore, we validated this using luciferase report assays that demonstrated that miR‐515‐5p interacts directly with the 3′ UTR of NRAS, PIK3C2B and MARK4 (Fig 2E and F) and showed the same targets to be down‐regulated by miR‐515‐5p in NSCLC cells (Fig 2D). This evidence concerns the gene PIK3C2B and non-small cell lung carcinoma.