Mechanically, Yang et al. reported that in lung adenocarcinoma cells from Kras/Tp53-mutant animals and human lung cancer cell lines, ZEB1 activates PI3K by depressing miR-200 targets, including amphiregulin (AREG), betacellulin (BTC), and GATA6 [33]. This evidence concerns the gene AREG and lung adenocarcinoma.