The extracellular endosulfatases (SULF1 and SULF2) are overexpressed in a wide assortment of human cancers [11,13,16] and SULF2, in particular, has been implicated, by us and others, as a driver of carcinogenesis in NSCLC [12], pancreatic carcinoma [17], malignant astrocytoma [15,16], colorectal carcinoma [27], and hepatocellular carcinoma [18]. This evidence concerns the gene SULF2 and hepatocellular carcinoma.