COMT Val158Met genotypes were also in Hardy–Weinberg equilibrium (Val/Val=109; Val/Met=190; Met/Met=95; χ2 (2)=1.45, P=0.484) and again there were no differences in distribution by gender (χ2 (2)=5.54, P=0.136) or cannabis dependence (χ2 (2)=3.14, P=0.792). The gene discussed is COMT; the disease is cannabis dependence.