NLGN2 and Anxiety: In this way, IL would not only lead to an activation of the downstream central nucleus of the amygdala,12, 13 but also lead to inhibition of the ipsilateral PrL, resulting in reduced activation of the basal amygdala nucleus and finally an anxiolytic effect.14, 15 In addition, we investigated whether deletion of Nlgn2 would influence inhibitory transmission from IL to PrL, and thus may be causally involved in increased anxiety-like behaviors that have been reported in these mice.37, 38