Deletion of Nlgn2 perturbs GABAergic and glycinergic synaptic transmissions and leads to a loss of postsynaptic specializations.33, 34, 35, 36, 37 As a consequence of this, Nlgn2-KO mice demonstrate heightened anxiety-related behavior on multiple measures.38 Given the broad expression of Nlgn2 at inhibitory synapses throughout the brain,31 this selective anxiety-related phenotype is somehow surprising. This evidence concerns the gene NLGN2 and Anxiety.