Importantly, TCGA data analysis revealed that, similarly to lung adenocarcinomas, OTUB1 overexpression in colorectal cancer is mutually exclusive with KRAS mutations (co‐occurrence log odds ratio: −3; P‐value: 0.003), whereas RAS genes are rarely mutated in prostate and breast cancers (Karnoub & Weinberg, 2008). This evidence concerns the gene OTUB1 and colorectal cancer.