Correlation analysis revealed that increased expression of OTUB1 (co‐occurrence log odds ratio: −1.478; P‐value: 0.014) or a gain of the OTUB1 locus (co‐occurrence log odds ratio: −0.796; P‐value: 0.017) and the mutation status of KRAS were mutually exclusive (Fig 4A), suggesting that OTUB1 overexpression may play a crucial role in tumorigenesis especially in lung adenocarcinomas harboring wt KRAS. This evidence concerns the gene KRAS and lung adenocarcinoma.